Breast Cancer

Scientists at University of Calabria release new data on breast cancer

Published in Women's Health Weekly, November 26th, 2009

According to recent research from Italy, "In situ estrogen production by aromatase conversion from androgens plays an important role in breast tumor promotion. Here, we show that 17 beta-estradiol (E-2) can rapidly enhance aromatase enzymatic activity through an increase of aromatase protein phosphorylation in breast cancer cell lines."

"In vivo labeling experiments and site-directed mutagenesis studies demonstrated that phosphorylation of the 361-tyrosine residue is crucial in the up-regulation of aromatase activity under E-2 exposure. Our results demonstrated a direct involvement of nonreceptor tyrosine-kinase c-Src in E-2-stimulated aromatase activity because...

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Source: Women's Health Weekly (2009-11-26)

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