Antisense Technology
Researchers at University of Nottingham publish new data on antisense technology
Published in Women's Health Weekly, January 28th, 2010
According to a study from Nottingham, the United Kingdom, "The antisense promoter of human LINE-1 (L1) retroelements can direct transcription of adjacent unique genomic sequences generating chimeric RNAs, which can perturb transcription of neighbouring genes. As L1 elements constitute 17% of the human genome, chimeric transcription is potentially widespread, but the extent to which this Occurs is largely unknown."
"Using a genome-wide screen we have isolated novel chimeric transcripts that are unique to breast cancer cell lines, primary tumours and colon cancer cells. Expression of the cancer-specific chimeric transcripts can be induced in non-malignant breast...
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