Anti-Infectives
Research from L. Gavard et al has provided new information about anti-infectives
Published in Women's Health Weekly, February 4th, 2010
According to recent research from Chatenay-Malabry, France, "The perfused cotyledon model is a very useful method to study placental transfer of drugs. Here we studied placental transfer of the human immunodeficiency virus protease inhibitor nelfinavir using the non-recirculating dual human placental perfusion with a main goal to determining the clearance index of nelfinavir as related to maternal concentrations, and analyze the conditions under which ex vivo and in vivo data can be correlated."
"Thirteen human cotyledons, obtained after uneventful term pregnancies, were perfused in an open double circuit with nelfinavir (320-4436 mu g/l and a freely diffusing marker...
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