Breast Cancer

Scientists at Yeshiva University release new data on breast cancer

Published in Women's Health Weekly, March 4th, 2010

"Resistance to anti-estrogen therapy is a major clinical concern in treatment of breast cancer. Estrogen-independent phosphorylation of estrogen receptor alpha, specifically on Ser167, is one of the contributing causes to development of resistance, and a prognostic marker for the disease," scientists in the United States report.

"Here, we dissect the signaling pathways responsible for Ser167 phosphorylation. We report that the mTOR/S6K1 and MAPK/RSK contribute non-overlapping inputs into ER alpha activation via Ser167 phosphorylation," wrote R.L. Yamnik and colleagues, Yeshiva University.

The researchers concluded: "This cooperation may be targeted...

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Source: Women's Health Weekly (2010-03-04)

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