Ovariectomy
New ovariectomy research has been reported by scientists at University Medical Center, Institute of Anatomy
Published in Women's Health Weekly, March 25th, 2010
New investigation results, 'Aromatase inhibitors induce spine synapse loss in the hippocampus of ovariectomized mice,' are detailed in a study published in Endocrinology. "Recently, inhibition of estrogen synthesis by aromatase inhibitors has become a favored therapy for breast cancer in postmenopausal women. Estrogen is, however, important for synapse formation in the hippocampus," investigators in Hamburg, Germany report.
"Inhibition of aromatase induces spine synapse loss in organotypic hippocampal slice cultures. We therefore studied the effect of systemic treatment with the potent aromatase inhibitor letrozole on spine synapse formation and synaptic proteins...
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