Breast Cancer
New research on breast cancer from University of Toronto summarized
Published in Women's Health Weekly, April 15th, 2010
"Our goal in this study was to elucidate the mechanisms by which methotrexate radiosensitizes HER2-positive human breast cancer cells to the Auger electron emitter In-111-trastuzumab modified with nuclear-localization sequence peptides (In-111-NLS- trastuzumab) and to compare these mechanisms with the potential sensitizing effects of paclitaxel and doxorubicin when combined with this radiopharmaceutical. Experiments were performed in MDA-MB-231 human breast cancer cells, their HER2-transfected subclones (231-H2N), and 2 trastuzumab-resistant variants (trastuzumab-resistant-1 and -2 [TrR1 and TrR2])," scientists in Toronto, Canada report.
"Effects of coexposure of these...
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