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Atopic Dermatitis

Research in the area of atopic dermatitis reported from W. Baumer and colleagues

Published in Women's Health Weekly, April 15th, 2010

"Miltefosine is currently marketed for treatment of skin metastasis of breast cancer and leishmaniasis. The mechanism of action is not fully understood, however, miltefosine is considered to be a prototype lipid raft modulator," scientists in Magdeburg, Germany report.

"The compound was shown to inhibit anti-IgE induced histamine release from human skin mast cells. After topical treatment it reduced skin reaction in allergic human volunteers undergoing a skin prick test. The aim of this study was to test whether miltefosine could also modify T-cell signalling and whether the drug may be useful for the treatment of atopic dermatitis. Miltefosine (20 mc M) inhibited...

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