Current study results from the report, 'Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovariancarcinoma,' have been published. "Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression. Functionally, L1CAM promotes tumor cell invasion and motility, augments tumor growth in nude mice, and facilitates experimental tumor metastasis," scientists writing in the journal Cancer Research report.
"These functional features qualify L1 as an interesting target molecule for tumor therapy. Here, we generated a series of novel monoclonal antibodies (mAb) to the L1CAM ectodomain that...
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