Breast Cancer
Findings from London Research Institute in breast cancer reported
Published in Women's Health Weekly, October 21st, 2010
Scientists discuss in 'Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility' new findings in breast cancer. According to recent research from London, the United Kingdom, "Here we use intravital imaging to demonstrate a reversible transition to a motile state as breast cancer cells spread. Imaging primary tumours revealed heterogeneity in cell morphology and motility."
"Two distinct modes of motility were observed: collective and single-celled. By monitoring the localization of Smad2 and the activity of a TGFbeta-dependent reporter gene during breast cancer cell dissemination, we demonstrate that TGFbeta...
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