Data from McGill University, Faculty of Dentistry advance knowledge in breast cancer

Investigators publish new data in the report 'Tumor-supportive and osteoclastogenic changes induced by breast cancer-derived factors are reversed by inhibition of {gamma}-secretase.' "During breast cancer metastasis to bone, tumor cells home to bone marrow, likely targeting the stem cell niche, and stimulate osteoclasts, which mediate osteolysis required for tumor expansion. Although osteoblasts contribute to the regulation of the hematopoietic stem cell niche and control osteoclastogenesis through production of proresorptive cytokine RANKL (receptor activator of NF-'B ligand), their role in cancer metastases to bone is not fully understood," scientists in Montreal, Canada report.

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