Breast Cancer
New breast cancer data have been reported by researchers at Hermes Biosciences, Inc.
Published in Women's Health Weekly, November 11th, 2010
A report, 'Development of a highly stable and targetable nanoliposomal formulation of topotecan,' is newly published data in Journal of Controlled Release. According to recent research published in the Journal of Controlled Release, "Topotecan (TPT), a highly active anticancer camptothecin drug, would benefit from nanocarrier-mediated site-specific and intracellular delivery because of a labile lactone ring whose hydrolysis inactivates the drug, poor cellular uptake resulting from both lactone hydrolysis and a titratable phenol hydroxyl, and the schedule-dependency of its efficacy due to its mechanism of action. We have encapsulated topotecan in liposomes using transmembrane...
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