Breast Cancer
Reports summarize breast cancer study results from K.T. Huang and co-researchers
Published in Women's Health Weekly, November 11th, 2010
"Hypoxia-inducible factor-1 (HIF-1) activity is regulated by prolyl hydroxylase (PHD1, PHD2, PHD3) and factor inhibiting HIF-1 (FIH) that target the alpha subunit of HIF-1 (HIF-1 alpha) for proteosomal degradation. We hypothesised that the elevated HIF-1 alpha level is due in some tumours to epigenetic silencing by DNA hypermethylation of the promoter region of one or more of the PHDs and FIH genes," scientists in Melbourne, Australia report.
"The aims were to define the presence or absence of promoter methylation of PHDs and FIH in cell lines of various sources and breast carcinomas and, if present, determine its effect on mRNA and protein expression. Tumour cell lines...
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