Breast Cancer
Data from Keio University, Department of Pathology advance knowledge in breast cancer
Published in Women's Health Weekly, December 30th, 2010
2010 DEC 30 -- Researchers detail in 'Connective tissue growth factor is a substrate of ADAM28,' new data in breast cancer. "ADAM28, a member of the ADAM (a disintegrin and metalloproteinase) gene family, is over-expressed by carcinoma cells and the expression correlates with carcinoma cell proliferation and progression in human lung and breast carcinomas. However, information about substrates of ADAM28 is limited," scientists in Tokyo, Japan report.
"We screened interacting molecules of ADAM28 in human lung cDNA library by yeast two-hybrid system and identified connective tissue growth factor (CTGF). Binding of CTGF to proADAM28 was demonstrated by yeast...
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