Breast Cancer
Studies from University of Lausanne further understanding of breast cancer
Published in Women's Health Weekly, January 6th, 2011
2011 JAN 6 -- New investigation results, 'An ultra performance liquid chromatography-tandem MS assay for tamoxifen metabolites profiling in plasma: first evidence of 4'-hydroxylated metabolites in breast cancer patients,' are detailed in a study published in Journal of Chromatography B, Analytical Technologies In the Biomedical and Life Sciences. "There is increasing evidence that the clinical efficacy of tamoxifen, the first and most widely used targeted therapy for estrogen-sensitive breast cancer, depends on the formation of the active metabolites 4-hydroxy-tamoxifen and 4-hydroxy-N-desmethyl-tamoxifen (endoxifen). Large inter-individual variability in endoxifen...
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