Small Interference RNAs (siRNAs)

Data on Small Interference RNAs (siRNAs) Discussed by Researchers at University of Lyon

Published in Women's Health Weekly, February 3rd, 2011

2011 FEB 3 -- According to recent research from Lyon, France, "ZNF217 is a candidate oncogene located at 20q13, a chromosomal region frequently amplified in breast cancers. The precise mechanisms involved in ZNF217 pro-survival function are currently unknown, and utmost importance is given to deciphering the role of ZNF217 in cancer therapy response."

"We provide evidence that stable overexpression of ZNF217 in MDA-MB-231 breast cancer cells conferred resistance to paclitaxel, stimulated cell proliferation in vitro associated with aberrant expression of several cyclins, and increased tumor growth in mouse xenograft models. Conversely, siRNA-mediated...

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Source: Women's Health Weekly (2011-02-03)

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