Study Data from K. Ohgi and Colleagues Update Understanding of Osteoporosis

2011 FEB 10 -- Data detailed in 'Antibodies against ClC7 inhibit extracellular acidification-induced Cl' currents and bone resorption activity in mouse osteoclasts' have been presented. "The Cl' channel/transporter ClC7 is crucial for osteoclastic bone resorption and might become a therapeutic target for osteoporosis. In this study, we raised anti-ClC7 polyclonal antibodies against three different peptide sequences, including G215, P249, and R286, which are the mutation regions found in autosomal dominant osteopetrosis type II patients and examined the effects of these antibodies on the ClC7 Cl' current induced by extracellular acidification (acid-activated Cl' current) using...

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