Breast Cancer
New Breast Cancer Study Results from University of Heidelberg Described
Published in Women's Health Weekly, February 10th, 2011
2011 FEB 10 -- Research findings, 'Knockdown of caveolin-1 decreases activity of breast cancer resistance protein (BCRP/ABCG2) and increases chemotherapeutic sensitivity,' are discussed in a new report. "The ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) is supposed to be a major determinant of the multidrug resistance phenotype of tumors by extruding chemically diverse cytostatic drugs out of tumor cells. BCRP physically and possibly also functionally interacts with caveolin-1 (CAV1, encoded by Cav1), an integral membrane protein of lipid rafts important for signal transduction and membrane trafficking," investigators in Heidelberg, Germany...
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