Breast Cancer

Studies from K. Kikuchi and Co-Researchers Yield New Data on Breast Cancer

Published in Women's Health Weekly, March 10th, 2011

2011 MAR 10 -- According to recent research from Yokohama, Japan, "Invasion of MDA-MB-231 breast cancer cells into three-dimensional (3-D) type I-collagen matrices depends on TGF-alpha. We characterized the steps of invasion mediated by TGF-alpha."

"Cell migration, as observed by videomicroscopy, was effectively stimulated by collagen, suggesting that TGF-alpha may specifically participate in the invasion of a 3-D collagen matrix. We assessed the role of small GTPases of the Rho family in the invasion. Cdc42 was found to be necessary for invasion but dispensable for cell migration," wrote K. Kikuchi and colleagues.

The researchers...

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Source: Women's Health Weekly (2011-03-10)

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