Breast Cancer
Studies from Kanagawa Cancer Center Yield New Data on Breast Cancer
Published in Women's Health Weekly, March 24th, 2011
2011 MAR 24 -- New investigation results, 'Invasion of breast cancer cells into collagen matrix requires TGF-a and Cdc42 signaling,' are detailed in a study published in Febs Letters. "Invasion of MDA-MB-231 breast cancer cells into three-dimensional (3-D) type I-collagen matrices depends on TGF-a. We characterized the steps of invasion mediated by TGF-a," scientists in Yokohama, Japan report.
"Cell migration, as observed by videomicroscopy, was effectively stimulated by collagen, suggesting that TGF-a may specifically participate in the invasion of a 3-D collagen matrix. We assessed the role of small GTPases of the Rho family in the invasion. Cdc42...
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