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Genetics and Ovarian Cancer

Reports Outline Genetics and Ovarian Cancer Study Findings from V. Stegel and Colleagues

Published in Women's Health Weekly, April 21st, 2011

2011 APR 21 -- According to recent research published in the journal BMC Medical Genetics, "The BRCA1 and BRCA2 mutation spectrum and mutation detection rates according to different family histories were investigated in 521 subjects from 322 unrelated Slovenian cancer families with breast and/or ovarian cancer. The BRCA1 and BRCA2 genes were screened using DGGE, PTT, HRM, MLPA and direct sequencing."

"Eighteen different mutations were found in BRCA1 and 13 in BRCA2 gene. Mutations in one or other gene were found in 96 unrelated families. The mutation detection rates were the highest in the families with at least one breast and at least one ovarian...

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