Breast Cancer
Findings from K.V. Nielsen et al in Breast Cancer Reported
Published in Women's Health Weekly, July 14th, 2011
2011 JUL 14 -- New investigation results, "Amplification of ESR1 may predict resistance to adjuvant tamoxifen in postmenopausal patients with hormone receptor positive breast cancer," are detailed in a study published in Breast Cancer Research and Treatment. According to the authors of a study from Glostrup, Denmark, "The estrogen receptor (ER) is the target of tamoxifen, but endocrine therapies do not benefit all patients with ER positive tumors. We therefore hypothesized that copy number changes in the ESR1 gene, encoding ER, confer resistance."
"Within a consecutive series of ER positive, postmenopausal patients allocated to 5 years tamoxifen, we...
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