Breast Cancer

CSHL team identifies enzyme that is an important regulator of aggressive breast cancer development

Published in Women's Health Weekly, July 21st, 2011

2011 JUL 21 -- Cold Spring Harbor, NY - Researchers at Cold Spring Harbor Laboratory (CSHL) have identified an enzyme that appears to be a significant regulator of breast cancer development. Called PTPN23, the enzyme is a member of a family called protein tyrosine phosphatases, or PTPs, that plays a fundamental role in switching cell signaling on and off.

When the scientists suppressed the expression of PTPN23 in human mammary cells, they noted a cascade of effects that included the cells breaking away from their anchors; their scattering; and their invasion through extracellular matrix (essentially, cells' mooring in tissue). These are the hallmarks of...

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Source: Women's Health Weekly (2011-07-21)

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