Breast Cancer
Study Data from R. Fujita and Co-Authors Update Knowledge of Breast Cancer
Published in Women's Health Weekly, August 18th, 2011
2011 AUG 18 -- According to the authors of a study from London, United Kingdom, "POU4F2/Brn-3b transcription factor (referred to as Brn-3b) is elevated in > 60% of breast cancers and profoundly alters growth and behaviour of cancer cells by regulating distinct subsets of target genes. Previous studies showed that Brn-3b was required to maximally transactivate small heat shock protein, HSPB1/Hsp-27 (referred to as Hsp-27), and consequently, Brn-3b expression correlated well with Hsp27 levels in human breast biopsies."
"In these studies, we showed that Brn-3b is increased in MCF7 breast cancer cells that survive following treatment with chemotherapeutic...
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