Breast Cancer

Albany Medical College Publishes Research in Breast Cancer

Published in Women's Health Weekly, August 25th, 2011

2011 AUG 25 -- "Progesterone (Pg) promotes normal breast development during pregnancy and lactation and increases the risk of developing basal-type invasive breast cancer. However, the mechanism of action of Pg has not been fully understood," scientists in Albany, New York report.

"In this study, we demonstrate that the mRNA and protein expression of Klf5, a pro-proliferation transcription factor in breast cancer, was dramatically up-regulated in mouse pregnant and lactating mammary glands. Pg, but not estrogen and prolactin, induced the expression of Krupple-like factor 5 (KLF5) in multiple Pg receptor (PR)positive breast cancer cell lines. Pg induced the...

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Source: Women's Health Weekly (2011-08-25)

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