Women's Health
Reports Outline Women's Health Study Findings from Emory University
Published in Women's Health Weekly, September 22nd, 2011
2011 SEP 22 -- According to the authors of a study from Atlanta, Georgia, "Spontaneous 46,XX primary ovarian insufficiency (POI) is a term that describes ovarian dysfunction resulting in a range of abnormalities, from infertility to early menopause as the end stage (overt POI). The most common known genetic cause of 46,XX POI is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene."
"This 'premutation' is associated with overt POI (FXPOI) in similar to 20% of carrier women. Greater than 200 CGG copies results in methylation of the CGG repeats and subsequent silencing of the FMR1 gene, causing fragile X...
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