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Cervical Cancer

Research on Cervical Cancer Reported by Scientists at University of Orebro

Published in Women's Health Weekly, September 22nd, 2011

2011 SEP 22 -- "Hypermethylation of the O-6-MGMT, p14(ARF), p16(INK4a), RASSFIA and APC1A genes are unfavourable prognostic markers in colorectal cancer (CRC). We hypothesized that they could be related to prognosis also in cervical cancer," scientists in Orebro, Sweden report.

"Methylation was studied in DNA extracts from surgical specimens of cancer tissue by novel pyrosequencing methods. In 109 patients (90 squamous cell carcinomas, 19 adenocarcinomas), we found that hypermethylation of the APC1A gene promoter occurred in 8.3% of patients, and of p16(INK4a) in 1.8%. APC1A hypermethylation was significantly related to more advanced FIGO stage of the tumor...

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