Chlamydia
Findings from Massachusetts General Hospital Advance Knowledge in Chlamydia
Published in Women's Health Weekly, November 3rd, 2011
2011 NOV 3 -- "Chlamydia species are obligate intracellular pathogens that utilize a type three secretion system to manipulate host cell processes. Genetic manipulations are currently not possible in Chlamydia, necessitating study of effector proteins in heterologous expression systems and severely complicating efforts to relate molecular strategies used by Chlamydia to the biochemical activities of effector proteins," researchers in Boston, Massachusetts report.
"CopN is a chlamydial type three secretion effector that is essential for virulence. Heterologous expression of CopN in cells results in loss of microtubule spindles and metaphase plate formation...
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