Gender and Health

Findings from University of Kansas in Gender and Health Reported

Published in Women's Health Weekly, January 5th, 2012

2012 JAN 5 -- "Cytochrome P450 (Cyp) enzymes from the first four families (Cyp1-4) play a major role in metabolizing xenobiotics, affecting drug pharmacokinetics and chemical-induced toxicity. Due to cloning of the mouse genome, many novel Cyp isoforms have been identified, but their tissue distribution of expression is unknown," investigators in Kansas City, Kansas report.

"This study compared the tissue distribution of all 78 Cyps from the Cyp1-4 families in C57BL/6 mice providing not only an indication of which tissues novel Cyps may have their greatest importance but also a cohesive comparison of the tissue distribution of all Cyp1-4 isoforms....

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Source: Women's Health Weekly (2012-01-05)

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