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Breast Cancer

Findings from GeneKOR Broaden Understanding of Breast Cancer

Published in Women's Health Weekly, February 2nd, 2012

2012 FEB 2 -- "Multiple epidemiological studies have investigated rs1136201, a non-synonymous polymorphism of the human epidermal growth factor receptor-2 gene (HER2) resulting in the substitution of valine for isoleucine at codon 655 (Ile655Val) of the HER2 protein, as a risk factor for breast cancer. We searched multiple databases to identify genetic association studies investigating the effect of rs1136201 on breast cancer risk," scientists writing in the journal Cancer Epidemiology report.

"For each study we calculated unadjusted odds ratios (ORs) with their variance under additive, dominant, recessive and allele-frequency genetic models. Summary...

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