Endometrial Cancer

Research from T. Li and Co-Researchers Yields New Findings on Endometrial Cancer

Published in Women's Health Weekly, February 9th, 2012

2012 FEB 9 -- According to the authors of recent research published in the journal Molecular and Cellular Biochemistry, "Loss or mutation of the PTEN (phosphatase and tensin homologue deleted on chromosome 10) gene is associated with resistance to epidermal growth factor receptor (EGFR) inhibitors. However, the mechanism underlying remains elusive."

"In this study, we aimed to explore whether sensitivity to the EGFR tyrosine kinase inhibitor (TKI) is affected by PTEN status in endometrial cancer cells. PTEN siRNA and the PTEN gene were transfected into HEC-1A and Ishikawa endometrial cancer cells using lentiviral vectors. Cells were treated under...

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Source: Women's Health Weekly (2012-02-09)

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