Breast Cancer

Studies from R.J. Mehta et al Further Understanding of Breast Cancer

Published in Women's Health Weekly, February 23rd, 2012

2012 FEB 23 -- According to the authors of a study from Indianapolis, Indiana, "Forkhead box protein A1 (FOXA1) is a 'pioneer factor' that plays a role in controlling nearly 50% of estrogen receptor target genes. FOXA1 expression correlates with estrogen receptor (ER)-positivity especially in luminal subtype A breast cancers."

"The aim of this study was to investigate the precise role of FOXA1 in breast cancer using a large population-based cohort. Nuclear expression of FOXA1 was analyzed in a tissue microarray of 4,444 invasive breast cancer cases using immunohistochemistry and correlated with clinicopathologic variables using previously described methods...

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Source: Women's Health Weekly (2012-02-23)

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