Cervical Cancer

Data from M.W. Luczak and Colleagues Advance Knowledge in Cervical Cancer

Published in Women's Health Weekly, March 15th, 2012

2012 MAR 15 -- "The development of cervical cancer requires genetic and epigenetic factors which result in the persistence of a malignant phenotype. Cervical cancer exhibits also some unique differences from other solid tumors," scientists in Poznan, Poland report.

"Normal cervical stratified epithelia have characteristics of hypoxic tissue with over-expression of HIF-1 (hypoxia-inducible factor-1) transcription factor, which targets the transcription of over 70 genes involved in many aspects of cancer biology. One of the genes, which could be induced by HIF-1 is chemokine (C-X-C motif) receptor 4 (CXCR4). CXCR4 could also be epigenetically regulated by...

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Source: Women's Health Weekly (2012-03-15)

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