World Disease Weekly
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Diabetes Epidemiology
Newly identified IPF1 binding site mutation in insulin gene promoter may predispose to diabetes
September 5th, 2006
A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus. According to a research letter from the United States, "Autosomal dominant diabetes is a heterogeneous subtype of the disease usually characterised by early onset and a primary defect in insulin secretion. To date, six genes have been found to be associated with early-onset autosomal dominant diabetes, also called MODY. Five of them are transcription factors directly or indirectly involved in the process of insulin gene expression. Many regulatory enhancer elements, including the critical glucose response elements, have been identified in the...
Source: World Disease Weekly (2006-09-05)
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