World Disease Weekly
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Tuberculosis Diagnostics
IFN-gamma responses to mycobacterial antigens aid early diagnosis of TB
September 5th, 2006
Interferon-gamma responses to mycobacterial antigens can aid early diagnosis of tuberculosis infection. Researchers in the United States and Uganda report, "To determine immunologic and epidemiologic correlates of acute Mycobacterium tuberculosis infection in household contacts of infectious tuberculosis cases, we performed a prospective, community-based cohort study of index cases and their household contacts in Kampala, Uganda." "Contacts were evaluated for tuberculin skin test (TST) conversion over two years. Interferon-gamma expression was measured using a whole blood assay after stimulating with M. tuberculosis culture-filtrate,"...
Source: World Disease Weekly (2006-09-05)
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