World Disease Weekly
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Acid Reflux
Researchers discover how acid reflux leads to esophageal cancer
September 5th, 2006
A particular enzyme may offer an explanation for how acid reflux may lead to cancer of the esophagus, according to a recent study in the Journal of Biological Chemistry. The study found that the enzyme NOX5-S is affected by exposure to acid and that it produces stress on cells, activating genes that lead to DNA damage. For the first time, researchers have outlined the signaling pathway from cells damaged by acid, to the progression of esophageal cancer. They believe the same process may happen in the body when cells are exposed to acid reflux. "The role of acid is controversial. But we show that by exposing cells to acid for short periods of...
Source: World Disease Weekly (2006-09-05)
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