World Disease Weekly
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Bird Flu Therapy
Investigators at Agricultural Research Service, College Station publish new data on bird flu therapy
June 23rd, 2009
Fresh data on bird flu are presented in the report 'A single substitution in amino acid 184 of the NP protein alters the replication and pathogenicity of H5N1 avian influenza viruses in chickens.' According to a study from the United States, "Changes in the NP gene of H5N1 highly pathogenic avian influenza (HPAI) viruses have previously been shown to affect viral replication, alter host gene expression levels and affect mean death times in infected chickens. Five amino acids at positions 22, 184, 400, 406, and 423 were different between the two recombinant viruses studied." "In this study, we individually mutated the five amino acids that differed and determined that...
Source: World Disease Weekly (2009-06-23)
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