World Disease Weekly
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Enzyme Research
Research from S. Sasso and co-authors in the area of enzyme research published
August 4th, 2009
Investigators publish new data in the report 'Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner.' "Chorismate mutase catalyzes a key step in the shikimate biosynthetic pathway towards phenylalanine and tyrosine. Curiously, the intracellular chorismate mutase of Mycobacterium tuberculosis (MtCM; Rv0948c) has poor activity and lacks prominent active-site residues," scientists writing in the The EMBO Journal report. "However, its catalytic efficiency increases >100-fold on addition of DAHP synthase (MtDS; Rv2178c), another shikimate-pathway enzyme. The 2.35 A crystal structure of the...
Source: World Disease Weekly (2009-08-04)
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