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cancer weekly

Susan Hasty, Publisher
Table of Contents . . . December 14th, 2004
Non-Subscriber - Summaries Only
Related Areas: Other Issues in cancer weekly | Other Publications

Acute Myeloid Leukemia - Dual-specificity fusion toxin selective and potent agent for AML treatment

Breast Cancer - Ultrasound helpful when a woman feels a lump, but clinical exam is normal

Leukemia - CNS abnormalities characterized in pediatric leukemia patients

Ovarian Sex Cord-Stromal Tumor - Loss of heterozygosity at chromosome 19p13.3 indicates gene alteration in SCSTs

Renal Cancer - CD8+ cytotoxic T lymphocytes recognize renal carcinoma antigens

Alzheimer Disease - A novel presenilin 1 mutation (Y154N) discovered in early onset AD

Apoptosis - H2AX phosphorylation at short telomeres in T cells and fibroblasts demonstrated

Apoptosis - Rituximab/alemtuzumab induce caspase-independent apoptotic pathway in CLL cells

Biological Therapy - Autologous antitumor lymphocytes regress metastatic melanoma in cancer patients

Biomarkers - The ratio of VEGF-A to its soluble receptor changes in breast cancer patients

Bladder Cancer - Details of phase III trial with Urocidin revealed for treatment of bladder cancer

Breast Cancer - Black tea polyphenols may inhibit hormone-dependent breast tumors

Breast Cancer - Breast tumor expression of EGFR family proteins has prognostic value

Breast Cancer - Breast-conserving therapy in women with BRCA1/2-linked disease has pros, cons

Breast Cancer - CTCF not target of 16q22.1 loss in breast carcinoma

Breast Cancer - Computer-aided diagnosis algorithm differentiates benign from malignant lesions

Breast Cancer - Gene silencing molecules inhibit tumor growth

Breast Cancer - High geminin expression predicts adverse outcome in breast cancer patients

Breast Cancer - Study finds chemical attraction makes HER2-positive breast cancer invade organs

Breast Cancer - Tamoxifen acts quickly to prevent damaged breast cells from turning cancerous

Breast Cancer - Wide PPV variations seen in Finnish screening program similar to rest of Europe

Business Update - Company announces termination of Genasense agreements by Aventis

COX-2 Inhibitor - RNA-binding protein CUGBP2/COX-2-mediated PGE2 antagonistic in radiation damage

Cancer Genetics - Small risk of heritable cancer among patients in Scottish general practices

Cancer Genomics and Genetics - CDC50A, CDC50B, and CDC50C genes in silico characterized

Cancer Research - 'Handcuffing' and unpairing controls of P1 plasmid replication

Cancer Therapy - Biopharmaceutical firm develops anticancer immunotherapy based on IVIg

Cancer Therapy - Blocking enzyme could stop spread of cancer

Cancer Therapy - Down syndrome protein reduces tumor growth

Cancer Therapy - Drug-discovery alliance enters phase I clinical trials in cancer

Cancer Therapy - Enzon, partner announce the filing of a new drug submission to Health Canada

Cancer Therapy - Froedtert Hospital begins treating previously untreatable cancer patients

Cancer Therapy - G-quartet oligonucleotides targeting Stat3 protein fight cancer growth

Cancer Therapy - Study may lead to new means of improving existing cancer treatments

Cancer Therapy - Study: Combination treatment helps thyroid cancer patients live longer

Cancer Therapy - U.S. FDA approves Tarceva for patients with advanced non-small-cell lung cancer

Cancer Therapy - U.S. FDA grants fast track status to glufosfamide for treating pancreatic cancer

Cancer Vaccine - Antibody response improved after antigen-pulsed dendritic cell vaccine

Cancer Vaccine - Manipulating dendritic cell biology provides active immunotherapy of cancer

Cancer Vaccine - Mono-epitopic peptide-based vaccine induces regression of liver tumor

Cancer Vaccine - Unique antigens for therapeutic cancer vaccines reviewed

Carcinogenesis - A heme oxygenase-1 promoter polymorphism links betal chewing to oral cancer

Cardiology - Biotech company and university team up to develop therapeutics for unstable plaque

Cell Biology - Novel genetic screen used to identify Drosophila S-phase entry regulators

Cell Biology - Stem cells' repair skills might be linked to cancer

Cervical Cancer - FRA8C is involved in HPV integration and chromosomal translocations

Cervical Cancer - Report assesses anesthetic technique used in high-dose-rate brachytherapy

Chest Pain - Illinois hospital receives society's chest pain center accreditation

Chronic Lymphocytic Leukemia - Novel DNA cross-linking agent has potent/selective cytotoxicity in CLL B cells

Collaborations - Alliance formed to develop melanoma product MDX-010

Collaborations - Alliance to fight one of China's most pressing health problems: hepatitis B

Collaborations - Company announces expansion of relationship with Pfizer

Collaborations - Deal signed for U.S. sales agent for cancer therapy device

Colorectal Cancer - Proteomic assay used to determine P450 profile in colorectal tumor metastases

Complementary & Alternative Medicine - More research needed on complementary therapies

Diagnostics - G-CSF response before leukopenia predicts infection defense in HD chemotherapy

Diagnostics - Use of biomarkers to detect cervical dysplasia, cancer a 'success'

Drug Development - Abbreviated new drug application for antitumor cancer drug granted by U.S. FDA

Drug Development - Anti-tumor alkaloids isolated from Glycosmis arborea

Drug Development - European pharmaceutical company gets E.U. approval for bone marrow disorder drug

Drug Development - Pharmaceutical company announces new research collaboration

Endocrinology - Thyroid transcription factor-1 boosts radioiodide retention in thyroid cancer

Endometrial Ablation - Five studies evaluating NovaSure system presented at AAGL meeting

Environmental Health - Blood study inquiry planned in Tar Creek case

Environmental Health - Congress sets aside money for health study of former View Master workers

Finance - Biotech company reports third quarter 2004 financial results

Finance - Cancer vaccine maker files shelf registration statement

Finance - Cancer-focused company announces direct equity issuance

Finance - Cancer/inflammation-focused company reports smaller loss in Q3

Finance - City of Hope awarded $11.5 million for research

Finance - Epitope-focused company reports Q3 revenues of $2.1 million

Finance - Genomics company reports Q3 net losses of $27.2

Finance - Genomics-focused company reports Q3 losses

Finance - Pharmaceutical company reports third quarter 2004 financial results

Finance - Revenues decrease 44% for satraplatin maker

Free Radicals - Fullerene C₆₀ functionally replaces mitochondrial Mn superoxide dismutases

Gastroenterology - NK4 staunches gastric cancer-related peritoneal metastasis in mice

Gene Transfer - Therapy combining adenovirus vectors has increased transduction efficiency

Glioma - Glioma ezrin expression has prognostic value

Graft-versus-Host Disease - Chronic GvHD suppresses relapse in CML and ALL but not in AML

Head and Neck Cancer - Gene assays back up sentinel node navigation surgery in oral cancer patients

Head and Neck Cancer - Report seeks improved management of head and neck cancers

Healthcare Funding - Tobacco-tax backers fighting pre-emptive legislation

Hormone Therapy - Researchers continue to weigh in on estrogen monotherapy arm of WHI study

Human Papillomavirus Vaccine - HPV-like particles encapsidating IL-2 adjuvant enhanced immunogenicity

Immunology - Eosinophils secrete plasminogen activator inhibitor-2

Immunology - Local blockade of negative stimulatory molecules augments antitumor cytokines

Information Technology - Grid software developer selected by IBM to power world community research grid

Intraductal Carcinoma - Microvessel phenotypes are altered in pre-invasive breast lesions

Leukemia - Mast cell neoplasms may respond to target-specific approaches

Leukemia - Umbilical-cord blood works well against leukemia in adults as well as children

Liver Cancer - Company presents liver cancer treatment at vascular targeting agents meeting

Lung Cancer - Early results shed light on lung cancer screening advance

Lung Cancer - Long-term smokers avoid lung cancer risk if they quit smoking

Lung Cancer - S100A2 expression characterized in NSCLC tumors and normal cells

Lung Cancer - Utility of FDG-PET in workup reviewed

Lymphoma - Arthritis treatment may reactivate virus responsible for some lymphomas

Lymphoma - NK cells induce resistance to cytotoxic chemotherapy in B lymphoma cells

Mantle Cell Lymphoma - Rituximab plus thalidomide effective for relapsed/refractory MCL

Metastasis - Reovirus foils the growth of metastatic breast cancer brain lesions

Natural Products - beta-HIVS suppresses TNF receptor-associated protein 1 gene expression

Neurology - Combined gene therapy and cancer immunotherapy attack glioma in murine models

Nutrition - Antioxidant supplementation may reduce incidence of cancer in men

Nutrition - Group questions conclusions in recent vitamin E meta-analysis

Obesity - Excess weight tied to increased risk for dozens of conditions

Oncology - Biotech company announces commercial supply agreement for cancer treatment

Oncology - Biotech company announces initiation of Phase II trial for cancer treatment

Oncology - EXACT Sciences broadens relationship to include PIK3CA colorectal cancer marker

Oncology - Estrogen receptor beta makes breast cancer cells susceptible to retinoic acid

Oncology - Government, academic, medical collaboration launches Spanish cancer program

Oncology - Interleukin-6 may favor tumor-host interactions in uveal melanoma

Oncology - Matrix enzyme inhibitor predicts poor outcomes for esophageal cancer patients

Oncology - New census shows growth in PET/CT installations

Oncology - Perillyl alcohol inhibits angiogenesis

Oncology - Platelet activation shifts the angiogenic balance in cancer patients

Oncology - U.S. FDA accepts Onco-LIFE PMA supplement for filing

Oral Squamous Cell Carcinoma - Gene expression profile of invasive tumors characterized

Ovarian Cancer - CPT-11 plus mitomycin C may work against platinum-refractory disease

Paraneoplastic Neurologic Disorders - Pyridoxal phosphatase is a novel cancer autoantigen in the central nervous system

Patents - U.S. Patent issued for peptide used to diagnose, treat neuroectodermal tumors

Pediatric Health - Children's hospital launches Thanks & Giving campaign to fight childhood disease

Personnel - Cancer-focused biotech company names Rick Hamm general counsel

Personnel - Dean J. Mitchell appointed president and CEO of AGGRASTAT maker

Personnel - Oncology company announces change in senior management

Personnel - Tim Germann named VP of sales and marketing by genomics diagnostics company

Prostate Cancer - Coding sequence determined for orthologs of prostate cancer susceptibility gene

Prostate Cancer - First-ever Cs-131 brachytherapy seeds to treat prostate cancer implanted

Prostate Cancer - Ovine atadenovirus guides gene-directed enzyme prodrug therapy to cancer cells

Prostate Cancer - Primary tumor-derived human prostate cancer cells retain neoplastic phenotypes

Prostate Cancer - Provenge data: Vaccine therapy for prostate cancer is shown to extend survival

Pyomyositis - Bacterial pyomyositis increasing in HIV and non-HIV infected patients in the US

Radiation Poisoning - Chernobyl disaster caused cancer cases in Sweden

Radiotherapy - Granisetron is a good choice for combatting symptoms of radiation-induced nausea

Renal Cell Carcinoma - HIF1A gene polymorphisms associated with renal cell carcinoma phenotype

Restructuring - Pharmaceutical company announces plan to discontinue gene editing operations

Selenium - Bioavailable selenium not preferentially toxic to transformed hepatocytes

Stem Cell Research - Bryostatin-1 enhances maturation/antigen-presenting ability of dendritic cells

Stem Cell Research - Gfi-1 restricts proliferation and preserves functional integrity of HSCs

Stem Cell Transplantation - Alpha-erythropoietin + filgrastim improves outcome/cost balance of ASCT

Stem Cell Transplantation - Majority of SCT patients accept poor QOL for small chance of cure

Stem Cell Transplantation - Megakaryocyte engraftment follows reduced-intensity conditioning

Stem Cell Transplantation - Stem cells from donors with abnormal findings can be used for HCT

Stock Market - Cancer diagnostics company announces new stock symbol, name

Tobacco Use - Duke University study finds cigarettes cost a total of $40 a pack

Tobacco Use - Percentage of smokers increases in Alabama

Tobacco Use - Sioux City, Iowa, bans smoking on sidewalks near clinics

Transfusion - Report provides suggestions for blood transfusions for terminal patients

Tumor Pathology - Stromal VEGF is a diagnostic biomarker in mammary phyllodes tumors

Vaccine Development - IFN-gamma enables cross-presentation of protein antigen in Langerhans cells

Vaccine Development - Naked sequence-stabilized mRNA vaccine generates immunity to diverse antigens

Vaccine Development - Protein to antigen fusion heightens the efficacy of DNA cancer vaccine

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