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Breast Cancer
High geminin expression predicts adverse outcome in breast cancer patients
December 14th, 2004
Elevated geminin expression predicts adverse outcome in breast cancer patients. "Geminin inhibits DNA replication by preventing Cdt1 from loading minichromosome maintenance (MCM) proteins onto DNA," according to pathologists in England, who "investigated whether the frequency of geminin expression predicts clinical outcome in breast cancer." "Immunohistochemistry was used first to examine geminin expression in normal and malignant breast tissue (n=67)," noted M.A. Gonzalez and coauthors at the Hutchison/MRC Research Centre in Cambridge. "Correlations with cell-cycle parameters, pathological features, and clinical outcome were then determined using an...
Source: cancer weekly (2004-12-14)
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