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COX-2 Inhibitor
RNA-binding protein CUGBP2/COX-2-mediated PGE2 antagonistic in radiation damage
December 14th, 2004
RNA-binding protein CUGBP2 and COX-2-mediated PGE2 are antagonistic in radiation damage. "Damage to intestinal epithelium limits the use of ionizing radiation (IR) in cancer therapy. Prostaglandins (PGs), generated through the action of cyclooxygenase-1 (COX-1) and COX-2 protect the intestinal stem cells from IR. "In previous studies, we demonstrated that the RNA-binding protein CUGBP2 regulates the stability and translation of COX-2 mRNA by interacting with AU-rich sequences in 3' UTR," scientists in the United States report. "Here, we demonstrate a dynamic antagonistic relationship between CUGBP2 and COX-2. Both...
Source: cancer weekly (2004-12-14)
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