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Cancer Research
'Handcuffing' and unpairing controls of P1 plasmid replication
December 14th, 2004
Researchers from the National Cancer Institute in the United States have shown that the a phenomena called 'handcuffing' and unpairing are important in controlling the replication of plasmid P1. The P1 plasmid origin has an array of five binding sites (iterons) for the plasmid-encoded initiator protein RepA. Saturation of these sites is required for initiation. Iterons can also pair via their bound RepAs in a reaction called handcuffing. The mechanism is believed to be the key to negatively controlling initiation. "Here we have determined some of the mechanistic details of the reaction," wrote N. Das and colleagues. ...
Source: cancer weekly (2004-12-14)
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