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Cancer Therapy
G-quartet oligonucleotides targeting Stat3 protein fight cancer growth
December 14th, 2004
G-quartet oligonucleotides targeting Stat3 protein fight cancer growth. "Stat3 is a signaling molecular and oncogene activated frequently in many human malignancies including the majority of prostate, breast, and head and neck cancers; yet, no current chemotherapeutic approach has been implemented clinically that specifically targets Stat3. We recently developed G-rich oligodeoxynucleotides, which form intramolecular G-quartet structures (GQ-ODN), as a new class of Stat3 inhibitor. GQ-ODN targeted Stat3 protein directly inhibiting its ability to bind DNA," scientists in the United States report. "When delivered into cells using polyethyleneimine as...
Source: cancer weekly (2004-12-14)
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