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Carcinogenesis
A heme oxygenase-1 promoter polymorphism links betal chewing to oral cancer
December 14th, 2004
A heme oxygenase-1 promoter polymorphism links betal chewing to oral cancer. "Areca (betel) chewing is associated with the high incidence of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF) in Asians. Heme oxygenase-1 (HO-1), encoding an oxidative response protein, plays protective roles in cells. A (GT)n microsatellite repeat in HO-1 promoter shows polymorphisms and modulates the level of gene transcription," scientists writing in the British Journal of Cancer report. "We examined allelotypic frequencies of (GT)n repeats in 83 controls, 147 OSCC and 71 OSF. All subjects were male areca chewers....
Source: cancer weekly (2004-12-14)
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