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Cell Biology
Novel genetic screen used to identify Drosophila S-phase entry regulators
December 14th, 2004
A novel genetic screen has been used to identify Drosophila S-phase entry regulators. "Cyclin E together with its kinase partner Cdk2 is a critical regulator of entry into S phase," scientists in Australia noted. "To identify novel genes that regulate the G1 - to S-phase transition within a whole animal, we made use of a hypomorphic cyclin E mutation, DmcycEJP, which results in a tough eye phenotype." "We screened the X and third chromosome deficiencies, tested candidate genes, and carried out a genetic screen of 55,000 EMS or X-ray-mutagenized flies for second or third chromosome mutations that dominantly...
Source: cancer weekly (2004-12-14)
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