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Ovarian Sex Cord-Stromal Tumor
Loss of heterozygosity at chromosome 19p13.3 indicates gene alteration in SCSTs
December 14th, 2004
Loss of heterozygosity at chromosome 19p13.3 in sporadic ovarian sex cord-stromal tumors appears to target a gene, or genes, other than the STK11/LKB1 tumor-suppressor gene, researchers in Spain report. "Germ line mutations in the STK11/LKB1 tumor-suppressor gene (chromosome 19p13.3) are responsible for the Peutz-Jeghers syndrome (PJS). PJS patients frequently develop neoplasms of various organs," said N. Kato and colleagues, Hospital Santa Creu & Sant Pau, Barcelona. "Ovarian sex cord-stromal tumor (SCST) with annular tubules, which shows a characteristic morphology intermediate between granulosa cell and Sertoli cell tumors, is distinctively...
Source: cancer weekly (2004-12-14)
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