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Diagnostics



G-CSF response before leukopenia predicts infection defense in HD chemotherapy



December 14th, 2004

G-CSF response before leukopenia predicts infection defense in high dose chemotherapy.

According to recent research from Germany, "An active assessment of the host capacity to prevent infection during myelosuppression should be beneficial in patients receiving high-dose chemotherapy.

"A single dose of granulocyte colony-stimulating factor (G-CSF) (5 mcg/kg) was given to 57 patients with multiple myeloma early after the completion of 85 high-dose chemotherapy (melphalan 200 mg/m2) courses. This provoked a highly variable white blood cell (WBC) peak after 12 to 14 hours."

"The median WBC count was 21 000/mcL (range,...


Source: cancer weekly (2004-12-14)

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