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Alcohol Use
Damaged DNA adducts linked to alcoholic beverage-related carcinogenesis
October 25th, 2005
Damaged DNA adducts have been linked to alcoholic beverage-related carcinogenesis. "Alcoholic beverage consumption is classified as a known human carcinogen, causally related to an increased risk of cancer of the upper gastrointestinal tract. The formation of acetaldehyde from ethanol metabolism seems to be the major mechanism underlying this effect," researchers in the United States reported. "Acetaldehyde is carcinogenic in rodents and causes sister chromatid exchanges and chromosomal aberrations in human cells. The best-studied DNA adduct from acetaldehyde is N-2-ethyl-2'-deoxyguanosine, which is increased in liver DNA obtained from...
Source: cancer weekly (2005-10-25)
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