cancer weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of cancer weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Alcohol Use
S-adenosylmethionine averts liver cancer growth in alcohol hepatitis models
October 25th, 2005
S-adenosylmethionine (SAMEe) averts liver cancer growth in alcohol hepatitis models. "Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine adenosyltransferase (MAT), which catalyzes the biosynthesis of SAMe, the principal methyl donor and, in the liver, a precursor of glutathione. MAT1A is expressed mostly in the liver, whereas MAT2A is widely distributed," scientists writing in the journal Alcohol report. "MAT2A is induced in the liver during periods of rapid growth and dedifferentiation. In human hepatocellular carcinoma (HCC) MAT1A is replaced by MAT2A. This is important pathogenetically because MAT2A expression is...
Source: cancer weekly (2005-10-25)
|
