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Antiproliferative Agents
CSAB suppresses proliferation of neoplastic human HeLa cells
October 25th, 2005
CSAB suppresses the proliferation of neoplastic human HeLa cells. "A series of twenty alkyl-, halo-, and methoxy-aryl-substituted 2-[(carboxymethyl)sulfanyl]-4-oxo-4-arylbutanoic acids were synthesized. The new compounds, called CSAB, suppressed proliferation of human cervix carcinoma, HeLa cells, in vitro in a concentration range of .644 to 29.48 mcM/L," investigators in Serbia Montenegro reported. "Two compounds exhibit antiproliferative activity in sub-micromolar concentrations (16, 19). Five compounds act in low micromolar concentrations (<2 mcM/L). The most active compounds exert lower cytotoxicity toward healthy human peripheral blood...
Source: cancer weekly (2005-10-25)
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