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Apoptosis
Caspase-14 can be reactivated in epithelial tumors
October 25th, 2005
The normally silent gene caspase-14 can be reactivated in epithelial tumors under certain conditions. "Cysteine-dependent aspartate-specific proteases (caspases) are the cellular executors of apoptosis. Caspase-14 is the most divergent member of the family of mammalian caspases and displays a variety of unique characteristics," investigators in the United States reported. "It is expressed in a limited number of tissues and has the shortest amino acid sequence within the caspase protein family. During induction of apoptosis, it is not processed, whereas terminal differentiation in skin leads to cleavage of caspase-14. Here we show that 40% of lung...
Source: cancer weekly (2005-10-25)
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